Quetiapine is an atypical antipsychotic, used clinically in the treatment of schizophrenia, acute mania in bipolar disorders, and\nbipolar depression in adults. In this study, the effect of green tea extracts (GTE) on the pharmacokinetics of quetiapine (substrate\nof CYP3A4) was investigated in rats. Male Wistar albino rats received GTE (175mg/kg) or saline (control) by oral gavage for 7\ndays before a single intragastric administration of 25mg/kg quetiapine. Plasma concentrations of quetiapine were measured up to\n12 h after its administration by a validated ultraperformance liquid chromatography-tandem mass spectroscopy. Pretreatment with\nGTE produced significant reductions in the maximum plasma concentration and area under the curve of quetiapine by 45% and\n35%, respectively, compared to quetiapine alone. However, GTE did not produce significant change in elimination half-life and oral\nclearance of quetiapine. This study concluded that GTE may decrease the bioavailability of quetiapine when coadministered.
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